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Genomic Analysis of 18th-Century Kazakh Individuals and Their Oral Microbiome

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dc.contributor.author White, Anna E.
dc.contributor.author de-Dios, Toni
dc.contributor.author Carrión, Pablo
dc.contributor.author Bonora, Gian Luca
dc.contributor.author Llovera, Laia
dc.contributor.author Cilli, Elisabetta
dc.contributor.author Lizano, Esther
dc.contributor.author Khabdulina, Maral K.
dc.contributor.author Tleugabulov, Daniyar T.
dc.contributor.author Olalde, Iñigo
dc.contributor.author Marquès-Bonet, Tomàs
dc.contributor.author Balloux, François
dc.contributor.author Pettener, Davide
dc.contributor.author Dorp, Lucy van
dc.contributor.author Luiselli, Donata
dc.contributor.author Lalueza-Fox, Carles
dc.date.accessioned 2024-09-09T11:36:48Z
dc.date.available 2024-09-09T11:36:48Z
dc.date.issued 2021
dc.identifier.citation White, A.E.; de-Dios, T.; Carrión, P.; Bonora, G.L.; Llovera, L.; Cilli, E.; Lizano, E.; Khabdulina, M.K.; Tleugabulov, D.T.; Olalde, I.; et al. Genomic Analysis of 18th-Century Kazakh Individuals and Their Oral Microbiome. Biology 2021, 10, 1324. https://doi.org/10.3390/ biology10121324 ru
dc.identifier.issn 2079-7737
dc.identifier.other doi.org/10.3390/biology10121324
dc.identifier.uri http://rep.enu.kz/handle/enu/16124
dc.description.abstract The Asian Central Steppe, consisting of current-day Kazakhstan and Russia, has acted as a highway for major migrations throughout history. Therefore, describing the genetic composition of past populations in Central Asia holds value to understanding human mobility in this pivotal region. In this study, we analyse paleogenomic data generated from five humans from Kuygenzhar, Kazakhstan. These individuals date to the early to mid-18th century, shortly after the Kazakh Khanate was founded, a union of nomadic tribes of Mongol Golden Horde and Turkic origins. Genomic analysis identifies that these individuals are admixed with varying proportions of East Asian ancestry, indicating a recent admixture event from East Asia. The high amounts of DNA from the anaerobic Gram-negative bacteria Tannerella forsythia, a periodontal pathogen, recovered from their teeth suggest they may have suffered from periodontitis disease. Genomic analysis of this bacterium identified recently evolved virulence and glycosylation genes including the presence of antibiotic resistance genes predating the antibiotic era. This study provides an integrated analysis of individuals with a diet mostly based on meat (mainly horse and lamb), milk, and dairy products and their oral microbiome. ru
dc.language.iso en ru
dc.publisher Biology ru
dc.relation.ispartofseries Volume 10;Issue 12
dc.subject paleogenomics ru
dc.subject ancient pathogens ru
dc.subject Central Asian steppe ru
dc.subject red complex ru
dc.subject bacteria ru
dc.title Genomic Analysis of 18th-Century Kazakh Individuals and Their Oral Microbiome ru
dc.type Article ru


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