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Sustainable Production of Ajuga Bioactive Metabolites Using Cell Culture Technologies: A Review

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dc.contributor.author Popova, Elena
dc.contributor.author Titova, Maria
dc.contributor.author Tynykulov, Marat
dc.contributor.author Zakirova, Rano P.
dc.contributor.author Kulichenko, Irina
dc.contributor.author Prudnikova, Olga
dc.contributor.author Nosov, Alexander
dc.date.accessioned 2024-09-10T10:50:11Z
dc.date.available 2024-09-10T10:50:11Z
dc.date.issued 2023
dc.identifier.citation Popova, E.; Titova, M.; Tynykulov, M.; Zakirova, R.P.; Kulichenko, I.; Prudnikova, O.; Nosov, A. Sustainable Production of Ajuga Bioactive Metabolites Using Cell Culture Technologies: A Review. Nutrients 2023, 15, 1246. https:// doi.org/10.3390/nu15051246 ru
dc.identifier.issn 2072-6643
dc.identifier.other doi.org/10.3390/nu15051246
dc.identifier.uri http://rep.enu.kz/handle/enu/16165
dc.description.abstract The genus Ajuga (Lamiaceae) is rich in medicinally important species with biological activities ranging from anti-inflammatory, antitumor, neuroprotective, and antidiabetic to antibacterial, antiviral, cytotoxic, and insecticidal effects. Every species contains a unique and complex mixture of bioactive metabolites—phytoecdysteroids (PEs), iridoid glycosides, withanolides, neo-clerodane terpenoids, flavonoids, phenolics, and other chemicals with high therapeutic potential. Phytoecdysteroids, the main compounds of interest, are natural anabolic and adaptogenic agents that are widely used as components of dietary supplements. Wild plants remain the main source of Ajuga bioactive metabolites, particularly PEs, which leads to frequent overexploitation of their natural resources. Cell culture biotechnologies offer a sustainable approach to the production of vegetative biomass and individual phytochemicals specific for Ajuga genus. Cell cultures developed from eight Ajuga taxa were capable of producing PEs, a variety of phenolics and flavonoids, anthocyanins, volatile compounds, phenyletanoid glycosides, iridoids, and fatty acids, and demonstrated antioxidant, antimicrobial, and anti-inflammatory activities. The most abundant PEs in the cell cultures was 20-hydroxyecdysone, followed by turkesterone and cyasterone. The PE content in the cell cultures was comparable or higher than in wild or greenhouse plants, in vitro-grown shoots, and root cultures. Elicitation with methyl jasmonate (50–125 µM) or mevalonate and induced mutagenesis were the most effective strategies that stimulated cell culture biosynthetic capacity. This review summarizes the current progress in cell culture application for the production of pharmacologically important Ajuga metabolites, discusses various approaches to improve the compound yield, and highlights the potential directions for future interventions. ru
dc.language.iso en ru
dc.publisher Nutrients ru
dc.relation.ispartofseries Volume 15;Issue 5
dc.subject 20-hydroxyecdysone ru
dc.subject anthocyanins ru
dc.subject biomass accumulation ru
dc.subject callus ru
dc.subject elicitation ru
dc.subject iridoids ru
dc.subject phytoecdysteroids ru
dc.subject suspension cell culture ru
dc.subject turkesterone ru
dc.title Sustainable Production of Ajuga Bioactive Metabolites Using Cell Culture Technologies: A Review ru
dc.type Article ru


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