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Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

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dc.contributor.author Mukusheva, Gulim K.
dc.contributor.author Jalmakhanbetova, Roza I.
dc.contributor.author Shaibek, Altynay Zh.
dc.contributor.author Nurmaganbetova, Manshuk S.
dc.contributor.author Zhasymbekova, Aigerym R.
dc.contributor.author Nurkenov, Oralgazy A.
dc.contributor.author Akishina, Ekaterina A.
dc.contributor.author Kolesnik, Irina A.
dc.contributor.author Dikusar, Evgenij A.
dc.contributor.author Terpinskaya, Tatiana I.
dc.contributor.author Kulchitsky, Vladimir A.
dc.contributor.author Potkin, Vladimir I.
dc.contributor.author Pushkarchuk, Alexander L.
dc.contributor.author Lyakhov, Dmitry A.
dc.contributor.author Michels, Dominik L.
dc.date.accessioned 2024-09-11T05:02:32Z
dc.date.available 2024-09-11T05:02:32Z
dc.date.issued 2024
dc.identifier.citation Mukusheva, G.K.; Jalmakhanbetova, R.I.; Shaibek, A.Z.; Nurmaganbetova, M.S.; Zhasymbekova, A.R.; Nurkenov, O.A.; Akishina, E.A.; Kolesnik, I.A.; Dikusar, E.A.; Terpinskaya, T.I.; et al. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells. Molecules 2024, 29, 3246. https://doi.org/10.3390/ molecules29143246 ru
dc.identifier.issn 1420-3049
dc.identifier.other doi.org/10.3390/molecules29143246
dc.identifier.uri http://rep.enu.kz/handle/enu/16184
dc.description.abstract Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells. ru
dc.language.iso en ru
dc.publisher Molecules ru
dc.relation.ispartofseries Volume 29;Issue 14
dc.subject anabasine ru
dc.subject cytisine ru
dc.subject ureas ru
dc.subject isoxazole ru
dc.subject cytotoxic activity ru
dc.subject antiproliferative activity ru
dc.subject drug synergism ru
dc.subject quantum chemical modeling ru
dc.subject molecular docking ru
dc.title Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells ru
dc.type Article ru


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