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Diverse Biological Activity of Benzofuroxan/Sterically Hindered Phenols Hybrids

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dc.contributor.author Chugunova, Elena
dc.contributor.author Gibadullina, Elmira
dc.contributor.author Matylitsky, Kirill
dc.contributor.author Bazarbayev, Baurat
dc.contributor.author Neganova, Margarita
dc.contributor.author Volcho, Konstantin
dc.contributor.author Rogachev, Artem
dc.contributor.author Akylbekov, Nurgali
dc.contributor.author Tran Nguyen, Hoang Bao
dc.contributor.author Voloshina, Alexandra
dc.contributor.author Lyubina, Anna
dc.contributor.author Amerhanova, Syumbelya
dc.contributor.author Syakaev, Victor
dc.contributor.author Burilov, Alexander
dc.contributor.author Appazov, Nurbol
dc.contributor.author Zhanakov, Mukhtar
dc.contributor.author Kuhn, Leah
dc.contributor.author Sinyashin, Oleg
dc.contributor.author Alabugin, Igor
dc.date.accessioned 2024-09-11T07:21:13Z
dc.date.available 2024-09-11T07:21:13Z
dc.date.issued 2023
dc.identifier.citation Chugunova, E.; Gibadullina, E.; Matylitsky, K.; Bazarbayev, B.; Neganova, M.; Volcho, K.; Rogachev, A.; Akylbekov, N.; Nguyen, H.B.T.; Voloshina, A.; et al. Diverse Biological Activity of Benzofuroxan/Sterically Hindered Phenols Hybrids. Pharmaceuticals 2023, 16, 499. https://doi.org/ 10.3390/ph16040499 ru
dc.identifier.issn 1424-8247
dc.identifier.other doi.org/ 10.3390/ph16040499
dc.identifier.uri http://rep.enu.kz/handle/enu/16195
dc.description.abstract Combining two pharmacophores in a molecule can lead to useful synergistic effects. Herein, we show hybrid systems that combine sterically hindered phenols with dinitrobenzofuroxan fragments exhibit a broad range of biological activities. The modular assembly of such phenol/benzofuroxan hybrids allows variations in the phenol/benzofuroxan ratio. Interestingly, the antimicrobial activity only appears when at least two benzofuroxan moieties are introduced per phenol. The most potent of the synthesized compounds exhibit high cytotoxicity against human duodenal adenocarcinoma (HuTu 80), human breast adenocarcinoma (MCF-7), and human cervical carcinoma cell lines. This toxicity is associated with the induction of apoptosis via the internal mitochondrial pathway and an increase in ROS production. Encouragingly, the index of selectivity relative to healthy tissues exceeds that for the reference drugs Doxorubicin and Sorafenib. The biostability of the leading compounds in whole mice blood is sufficiently high for their future quantification in biological matrices. ru
dc.language.iso en ru
dc.publisher Pharmaceuticals ru
dc.relation.ispartofseries Volume 16;Issue 4
dc.subject benzofuroxan ru
dc.subject sterically hindered phenol ru
dc.subject anti-cancer activity ru
dc.subject cytotoxicity ru
dc.subject apoptosis ru
dc.subject ROS production ru
dc.title Diverse Biological Activity of Benzofuroxan/Sterically Hindered Phenols Hybrids ru
dc.type Article ru


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