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Effects of Internal Exposure of Radioactive 56MnO2 Particles on the Lung in C57BL Mice

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dc.contributor.author Abishev, Zhaslan
dc.contributor.author Ruslanova, Bakhyt
dc.contributor.author Apbassova, Saulesh
dc.contributor.author Chaizhunussova, Nailya
dc.contributor.author Shabdarbayeva, Dariya
dc.contributor.author Azimkhanov, Almas
dc.contributor.author Zhumadilov, Kassym
dc.contributor.author Stepanenko, Valeriy
dc.contributor.author Ivanov, Sergey
dc.contributor.author Shegay, Peter
dc.contributor.author Hoshi, Masaharu
dc.contributor.author Fujimoto, Nariaki
dc.date.accessioned 2024-09-11T07:44:11Z
dc.date.available 2024-09-11T07:44:11Z
dc.date.issued 2023
dc.identifier.issn 1467-3045
dc.identifier.other doi.org/10.3390/cimb45040209
dc.identifier.uri http://rep.enu.kz/handle/enu/16199
dc.description.abstract The investigation of the radiation effects of the atomic bombing in Hiroshima and Nagasaki has revealed concerns about the impact of the residual radioactive dust produced in the soil. Manganese-56 is one of the major radioisotopes produced by neutrons from the bomb; hence, we previously examined the biological effects of manganese dioxide-56 (56MnO2 ) in Wistar rats, in which significant changes were found in the lung. In the present study, ten-week-old male C57BL mice were exposed to three doses of radioactive 56MnO2 , stable MnO2 particles, or external γ-rays (2 Gy) to further examine the effects of 56MnO2 in a different species. The estimated absorbed radiation doses from 56MnO2 were 26, 96, and 250 mGy in the lung. The animals were examined at 3, 14, and 70 days post exposure. Histologically, no exposure-related changes were found in the lungs of any group. However, pulmonary mRNA expression of aquaporin 1, which is a useful marker for lung pathophysiology, was significantly elevated at 14 and 70 days, although no such changes were found in the mice exposed to external γ-rays (2 Gy). These data indicated that the inhalation exposure to 56MnO2 particles, with <250 mGy of organ doses, produced significant biological responses in the lung. ru
dc.language.iso en ru
dc.publisher Current Issues in Molecular Biology ru
dc.relation.ispartofseries Volume 45;Issue 4
dc.subject residual radiation ru
dc.subject internal radiation exposure ru
dc.subject radiation injury ru
dc.subject lung ru
dc.title Effects of Internal Exposure of Radioactive 56MnO2 Particles on the Lung in C57BL Mice ru
dc.type Article ru


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