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Effects of Radioactive 56MnO2 Particle Inhalation on Mouse Lungs: A Comparison between C57BL and BALB/c

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dc.contributor.author Abishev, Zhaslan
dc.contributor.author Ruslanova, Bakhyt
dc.contributor.author Apbassova, Saulesh
dc.contributor.author Shabdarbayeva, Dariya
dc.contributor.author Chaizhunussova, Nailya
dc.contributor.author Dyusupov, Altai
dc.contributor.author Azhimkhanov, Almas
dc.contributor.author Zhumadilov, Kassym
dc.contributor.author Stepanenko, Valeriy
dc.contributor.author Ivanov, Sergey
dc.contributor.author Shegay, Peter
dc.contributor.author Kaprin, Andrey
dc.contributor.author Hoshi, Masaharu
dc.contributor.author Fujimoto, Nariaki
dc.date.accessioned 2024-09-11T07:51:50Z
dc.date.available 2024-09-11T07:51:50Z
dc.date.issued 2023-12
dc.identifier.citation Abishev, Z.; Ruslanova, B.; Apbassova, S.; Shabdarbayeva, D.; Chaizhunussova, N.; Dyusupov, A.; Azhimkhanov, A.; Zhumadilov, K.; Stepanenko, V.; Ivanov, S.; et al. Effects of Radioactive 56MnO2 Particle Inhalation on Mouse Lungs: A Comparison between C57BL and BALB/c. Int. J. Mol. Sci. 2023, 24, 17605. https://doi.org/10.3390/ ijms242417605 ru
dc.identifier.issn 1422-0067
dc.identifier.other doi.org/10.3390/ijms242417605
dc.identifier.uri http://rep.enu.kz/handle/enu/16200
dc.description.abstract The effects of residual radiation from atomic bombs have been considered to be minimal because of its low levels of external radioactivity. However, studies involving atomic bomb survivors exposed to only residual radiation in Hiroshima and Nagasaki have indicated possible adverse health effects. Thus, we investigated the biological effects of radioactive dust of manganese dioxide 56 (56MnO2 ), a major radioisotope formed in soil by neutron beams from a bomb. Previously, we investigated C57BL mice exposed to 56MnO2 and found pulmonary gene expression changes despite low radiation doses. In this study, we examined the effects in a radiation-sensitive strain of mice, BALB/c, and compared them with those in C57BL mice. The animals were exposed to 56MnO2 particles at two radioactivity levels and examined 3 and 65 days after exposure. The mRNA expression of pulmonary pathophysiology markers, including Aqp1, Aqp5, and Smad7, and radiationsensitive genes, including Bax, Phlda3, and Faim3, was determined in the lungs. The radiation doses absorbed in the lungs ranged from 110 to 380 mGy; no significant difference was observed between the two strains. No exposure-related pathological changes were observed in the lungs of any group. However, the mRNA expression of Aqp1 was significantly elevated in C57BL mice but not in BALB/c mice 65 days after exposure, whereas no changes were observed in external γ-rays (2 Gy) in either strain. In contrast, Faim3, a radiation-dependently downregulated gene, was reduced by 56MnO2 exposure in BALB/c mice but not in C57BL mice. These data demonstrate that inhalation exposure to 56MnO2 affected the expression of pulmonary genes at doses <380 mGy, which is comparable to 2 Gy of external γ-irradiation, whereas the responses differed between the two mouse strains. ru
dc.language.iso en ru
dc.publisher International Journal of Molecular Sciences ru
dc.relation.ispartofseries Volume 24;Issue 24
dc.subject environmental residual radiation ru
dc.subject radiation-induced lung injury ru
dc.subject internal radiation exposure ru
dc.subject mouse strain differences ru
dc.title Effects of Radioactive 56MnO2 Particle Inhalation on Mouse Lungs: A Comparison between C57BL and BALB/c ru
dc.type Article ru


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