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Gut microbiome-immune interactions and their role in rheumatoid arthritis development

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dc.contributor.author Nurgaziyev, Madiyar
dc.contributor.author Issilbayeva, Argul
dc.contributor.author Bersimbaev, Rakhmetkazhi
dc.contributor.author Ilderbayev, Oralbek
dc.contributor.author Vinogradova, Elizaveta
dc.contributor.author Jarmukhanov, Zharkyn
dc.contributor.author Nurgozhina, Ayaulym
dc.contributor.author Sergazy, Shynggys
dc.contributor.author Kozhabergen, Nuray
dc.contributor.author Akhmetova, Zhanar
dc.contributor.author Meiramova, Assel
dc.contributor.author Chulenbayeva, Laura
dc.contributor.author Ibrayeva, Aigerim
dc.contributor.author Mukhanbetzhanov, Nurislam
dc.contributor.author Mukhanbetzhanova, Zhanel
dc.contributor.author Kozhakhmetov, Samat
dc.contributor.author Ainabekova, Bayan
dc.contributor.author Kushugulova, Almagul
dc.date.accessioned 2024-09-11T10:52:54Z
dc.date.available 2024-09-11T10:52:54Z
dc.date.issued 2024-07
dc.identifier.citation Nurgaziyev M, Issilbayeva A, Bersimbaev R, Ilderbayev O, Vinogradova E, Jarmukhanov Z, Nurgozhina A, Sergazy S, Kozhabergen N, Akhmetova Z, Meiramova A, Chulenbayeva L, Ibrayeva A, Mukhanbetzhanov N, Mukhanbetzhanova Z, Kozhakhmetov S, Ainabekova B, Kushugulova A. 2024. Gut microbiome-immune interactions and their role in rheumatoid arthritis development. PeerJ 12:e17477 DOI 10.7717/peerj.17477 ru
dc.identifier.issn 2167-8359
dc.identifier.other DOI 10.7717/peerj.17477
dc.identifier.uri http://rep.enu.kz/handle/enu/16214
dc.description.abstract Objective: The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on the development of rheumatoid arthritis. Methods: This study was performed in Astana, Kazakhstan, and included 77 Kazakh female patients older than 18 years, who met the American College of Rheumatology 2010 classification criteria for rheumatoid arthritis (RA), and 113 healthy controls. The DNA was extracted from fecal samples obtained from all study participants for subsequent sequencing at the 16S rRNA gene V1-V3 locus, facilitating the analysis of the gut microbiome. The Multiplex immunoassay was employed to measure the concentrations of inflammatory cytokines, chemokines, and immunoglobulins in both fecal and plasma samples. Results: Our taxonomic analysis revealed significant differences in the composition of the gut microbiota between the healthy control cohort and the cohort with rheumatoid arthritis RA. Alpha diversity was significantly lower in the RA group. Lachnospiraceae were the most abundant taxon and found to be crucial, showing correlations with immunological markers such as IL5. Additionally, Lachnospiraceae and Oscillospiraceae exhibited the most predictable power and distinguished the composition of both study groups. Conclusion: Our study identifies key differences in the gut microbiome of RA patients, revealing distinct microbial patterns and specific taxa abundance. We highlight potential biomarkers in immunological and bacterial pathways, offering insights into RA development and indicating possibilities for personalized treatment. ru
dc.language.iso en ru
dc.publisher PeerJ ru
dc.subject Rheumatoid arthritis ru
dc.subject Gut microbiome ru
dc.subject 16S rRNA ru
dc.subject Sequencing ru
dc.subject Immunology ru
dc.subject Cytokines ru
dc.subject Chemokines ru
dc.subject Metabolic pathways ru
dc.title Gut microbiome-immune interactions and their role in rheumatoid arthritis development ru
dc.type Article ru


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