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Synthesis and Investigation of Biological Activity of New Betulonic Acid Derivatives Containing 1,2,3-Triazole Fragments

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dc.contributor.author Jalmakhanbetova, Roza I.
dc.contributor.author Mukusheva, Gulim K.
dc.contributor.author Abdugalimov, Alisher Sh.
dc.contributor.author Zhumagalieva, Zharkyn Zh.
dc.contributor.author Dehaen, Wim
dc.contributor.author Anthonissen, Stijn
dc.contributor.author Suleimen, Yerlan M.
dc.contributor.author Seidakhmetova, Roza B.
dc.date.accessioned 2024-09-12T09:22:33Z
dc.date.available 2024-09-12T09:22:33Z
dc.date.issued 2024
dc.identifier.citation Jalmakhanbetova, R.I.; Mukusheva, G.K.; Abdugalimov, A.S.; Zhumagalieva, Z.Z.; Dehaen, W.; Anthonissen, S.; Suleimen, Y.M.; Seidakhmetova, R.B. Synthesis and Investigation of Biological Activity of New Betulonic Acid Derivatives Containing 1,2,3-Triazole Fragments. Molecules 2024, 29, 3149. https:// doi.org/10.3390/molecules29133149 ru
dc.identifier.issn 1420-3049
dc.identifier.other doi.org/10.3390/molecules29133149
dc.identifier.uri http://rep.enu.kz/handle/enu/16250
dc.description.abstract The results of this study showed that the compounds synthesized by the authors have significant potential due to their antibacterial and cytotoxic properties. The apparent antibacterial activity demonstrated by the compounds suggests that they are active antimicrobial agents against common microbial pathogens that cause various socially significant infectious diseases. Compound 6 showed pronounced antimicrobial activity against the Gram-positive test strain Staphylococcus aureus ATCC 6538, and compound 7 demonstrated pronounced antimicrobial activity against the Gram-negative test strain Escherichia coli ATCC 25922 (MIC = 6.3 µg/mL). This allowed us to consider these compounds to have great potential. ru
dc.language.iso en ru
dc.publisher Molecules ru
dc.relation.ispartofseries Volume 29;Issue 13
dc.subject betulonic acid ru
dc.subject triterpenoid ru
dc.subject lupane ru
dc.subject natural product ru
dc.subject chemical transformation ru
dc.subject synthesis ru
dc.subject spectroscopic method ru
dc.subject cytotoxicity ru
dc.subject antimicrobial activity ru
dc.title Synthesis and Investigation of Biological Activity of New Betulonic Acid Derivatives Containing 1,2,3-Triazole Fragments ru
dc.type Article ru


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