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The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

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dc.contributor.author Ibragimova, Milana
dc.contributor.author Kussainova, Assiya
dc.contributor.author Aripova, Akmaral
dc.contributor.author Bersimbaev, Rakhmetkazhi
dc.contributor.author Bulgakova, Olga
dc.date.accessioned 2024-09-12T09:44:22Z
dc.date.available 2024-09-12T09:44:22Z
dc.date.issued 2024
dc.identifier.citation Ibragimova, M.; Kussainova, A.; Aripova, A.; Bersimbaev, R.; Bulgakova, O. The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation. Cells 2024, 13, 550. https://doi.org/10.3390/ cells13060550 ru
dc.identifier.issn 2073-4409
dc.identifier.other doi.org/10.3390/cells13060550
dc.identifier.uri http://rep.enu.kz/handle/enu/16255
dc.description.abstract This review discusses the relationship between cellular senescence and radiation exposure. Given the wide range of ionizing radiation sources encountered by people in professional and medical spheres, as well as the influence of natural background radiation, the question of the effect of radiation on biological processes, particularly on aging processes, remains highly relevant. The parallel relationship between natural and radiation-induced cellular senescence reveals the common aspects underlying these processes. Based on recent scientific data, the key points of the effects of ionizing radiation on cellular processes associated with aging, such as genome instability, mitochondrial dysfunction, altered expression of miRNAs, epigenetic profile, and manifestation of the senescence-associated secretory phenotype (SASP), are discussed. Unraveling the molecular mechanisms of cellular senescence can make a valuable contribution to the understanding of the molecular genetic basis of age-associated diseases in the context of environmental exposure. ru
dc.language.iso en ru
dc.publisher Cells ru
dc.relation.ispartofseries Volume 13;Issue 6
dc.subject cellular senescence ru
dc.subject natural aging ru
dc.subject ionizing radiation ru
dc.subject DNA damage ru
dc.subject mitochondrial dysfunction ru
dc.subject miRNAs ru
dc.subject SASP ru
dc.title The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation ru
dc.type Article ru


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