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Internal doses in experimental mice and rats following exposure to neutron‑activated 56MnO2 powder: results of an international, multicenter study

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dc.contributor.author Stepanenko, Valeriy 
dc.contributor.author Kaprin, Andrey 
dc.contributor.author  Ivanov, Sergey
dc.contributor.author Shegay, Peter 
dc.contributor.author Zhumadilov, Kassym 
dc.contributor.author Petukhov, Aleksey 
dc.contributor.author Kolyzhenkov, Timofey 
dc.contributor.author Bogacheva, Viktoria 
dc.contributor.author Zharova, Elena 
dc.contributor.author  Iaskova, Elena
dc.contributor.author Chaizhunusova, Nailya 
dc.contributor.author Shabdarbayeva, Dariya 
dc.contributor.author Amantayeva, Gaukhar 
dc.contributor.author Baurzhan, Arailym 
dc.contributor.author Ruslanova, Bakhyt 
dc.contributor.author Abishev, Zhaslan 
dc.contributor.author Apbassova, Madina 
dc.contributor.author Kairkhanova, Ynkar 
dc.contributor.author Uzbekov, Darkhan 
dc.contributor.author Khismetova, Zaituna 
dc.contributor.author Zhunussov, Yersin 
dc.contributor.author Fujimoto, Nariaki 
dc.contributor.author Sato, Hitoshi 
dc.contributor.author Shichijo, Kazuko 
dc.contributor.author Nakashima, Masahiro 
dc.contributor.author Sakaguchi, Aya 
dc.contributor.author Toyoda, Shin 
dc.contributor.author Kawano, Noriyuki 
dc.contributor.author Ohtaki, Megu 
dc.contributor.author Otani, Keiko 
dc.contributor.author Endo, Satoru 
dc.contributor.author Yamamoto, Masayoshi 
dc.contributor.author Hoshi, Masaharu 
dc.date.accessioned 2024-09-18T07:00:50Z
dc.date.available 2024-09-18T07:00:50Z
dc.date.issued 2020-11
dc.identifier.issn 0301634X
dc.identifier.other DOI 10.1007/s00411-020-00870-x
dc.identifier.uri http://rep.enu.kz/handle/enu/16589
dc.description.abstract The experiment was performed in support of a Japanese initiative to investigate the biological efects of irradiation from residual neutron-activated radioactivity that resulted from the A-bombing. Radionuclide 56Mn (T1/2=2.58 h) is one of the main neutron-activated emitters during the frst hours after neutron activation of soil dust particles. In our previous studies (2016–2017) related to irradiation of male Wistar rats after dispersion of 56MnO2 powder, the internal doses in rats were found to be very inhomogeneous: distribution of doses among diferent organs ranged from 1.3 Gy in small intestine to less than 0.0015 Gy in some of the other organs. Internal doses in the lungs ranged from 0.03 to 0.1 Gy. The essential pathological changes were found in lung tissue of rats despite a low level of irradiation. In the present study, the dosimetry investigations were extended: internal doses in experimental mice and rats were estimated for various activity levels of dispersed neutronactivated 56MnO2 powder. The following fndings were noted: (a) internal radiation doses in mice were several times higher in comparison with rats under similar conditions of exposure to 56MnO2 powder. (b) When 2.74×108  Bq of 56MnO2 powder was dispersed over mice, doses of internal irradiation ranged from 0.81 to 4.5 Gy in the gastrointestinal tract (small intestine, stomach, large intestine), from 0.096 to 0.14 Gy in lungs, and doses in skin and eyes ranged from 0.29 to 0.42 Gy and from 0.12 to 0.16 Gy, respectively. Internal radiation doses in other organs of mice were much lower. (c) Internal radiation doses were signifcantly lower in organs of rats with the same activity of exposure to 56MnO2 powder (2.74×108  Bq): 0.09, 0.17, 0.29, and 0.025 Gy in stomach, small intestine, large intestine, and lungs, respectively. (d) Doses of internal irradiation in organs of rats and mice were two to four times higher when they were exposed to 8.0×108  Bq of 56MnO2 (in comparison with exposure to 2.74×108  Bq of 56MnO2). (e) Internal radiation doses in organs of mice were 7–14 times lower with the lowest 56MnO2 amount (8.0×107  Bq) in comparison with the highest amount, 8.0×108  Bq, of dispersed 56MnO2 powder. The data obtained will be used for interpretation of biological efects in experimental mice and rats that result from dispersion of various levels of neutron-activated 56MnO2 powder, which is the subject of separate studies. ru
dc.language.iso en ru
dc.publisher Radiation and Environmental Biophysics ru
dc.relation.ispartofseries Том 59,;Выпуск 4, Страницы 683 - 692
dc.subject 56Mn  ru
dc.subject Neutron activation  ru
dc.subject Dispersion of radioactivity  ru
dc.subject Radioactive dust  ru
dc.subject Internal irradiation  ru
dc.subject Experimental mice and rats ru
dc.title Internal doses in experimental mice and rats following exposure to neutron‑activated 56MnO2 powder: results of an international, multicenter study ru
dc.type Article ru


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