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Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

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dc.contributor.author Dukenbayev, Kanat
dc.contributor.author Korolkov, Ilya V.
dc.contributor.author Tishkevich, Daria I.
dc.contributor.author Kozlovskiy, Artem L.
dc.contributor.author Trukhanov, Sergey V.
dc.contributor.author Gorin, Yevgeniy G.
dc.contributor.author Shumskaya, Elena E.
dc.contributor.author Kaniukov, Egor Y.
dc.contributor.author Vinnik, Denis A.
dc.contributor.author Zdorovets, Maxim V.
dc.contributor.author Anisovich, Marina
dc.contributor.author Trukhanov, Alex V.
dc.contributor.author Tosi, Daniele
dc.contributor.author Molardi, Carlo
dc.date.accessioned 2024-09-18T07:50:10Z
dc.date.available 2024-09-18T07:50:10Z
dc.date.issued 2019
dc.identifier.issn 2079-4991
dc.identifier.other doi:10.3390/nano9040494
dc.identifier.uri http://rep.enu.kz/handle/enu/16606
dc.description.abstract Magnetic Fe3O4 nanoparticles (NPs) and their surface modification with therapeutic substances are of great interest, especially drug delivery for cancer therapy, including boron-neutron capture therapy (BNCT). In this paper, we present the results of boron-rich compound (carborane borate) attachment to previously aminated by (3-aminopropyl)-trimethoxysilane (APTMS) iron oxide NPs. Fourier transform infrared spectroscopy with Attenuated total reflectance accessory (ATR-FTIR) and energy-dispersive X-ray analysis confirmed the change of the element content of NPs after modification and formation of new bonds between Fe3O4 NPs and the attached molecules. Transmission (TEM) and scanning electron microscopy (SEM) showed Fe3O4 NPs’ average size of 18.9 nm. Phase parameters were studied by powder X-ray diffraction (XRD), and the magnetic behavior of Fe3O4 NPs was elucidated by Mössbauer spectroscopy. The colloidal and chemical stability of NPs was studied using simulated body fluid (phosphate buffer—PBS). Modified NPs have shown excellent stability in PBS (pH = 7.4), characterized by XRD, Mössbauer spectroscopy, and dynamic light scattering (DLS). Biocompatibility was evaluated in-vitro using cultured mouse embryonic fibroblasts (MEFs). The results show us an increasing of IC50 from 0.110 mg/mL for Fe3O4 NPs to 0.405 mg/mL for Fe3O4-Carborane NPs. The obtained data confirm the biocompatibility and stability of synthesized NPs and the potential to use them in BNCT. ru
dc.language.iso en ru
dc.publisher Nanomaterials ru
dc.relation.ispartofseries Volume 9;Issue 4
dc.subject magnetic nanoparticles ru
dc.subject iron oxide ru
dc.subject surface functionalization ru
dc.subject APTMS ru
dc.subject carborane ru
dc.title Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy ru
dc.type Article ru


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