Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

Mukusheva, Gulim K.; Jalmakhanbetova, Roza I.; Shaibek, Altynay Zh.; Nurmaganbetova, Manshuk S.; Zhasymbekova, Aigerym R.; Nurkenov, Oralgazy A.; Akishina, Ekaterina A.; Kolesnik, Irina A.; Dikusar, Evgenij A.; Terpinskaya, Tatiana I.; Kulchitsky, Vladimir A.; Potkin, Vladimir I.; Pushkarchuk, Alexander L.; Lyakhov, Dmitry A.; Michels, Dominik L.

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dc.contributor.author	Mukusheva, Gulim K.
dc.contributor.author	Jalmakhanbetova, Roza I.
dc.contributor.author	Shaibek, Altynay Zh.
dc.contributor.author	Nurmaganbetova, Manshuk S.
dc.contributor.author	Zhasymbekova, Aigerym R.
dc.contributor.author	Nurkenov, Oralgazy A.
dc.contributor.author	Akishina, Ekaterina A.
dc.contributor.author	Kolesnik, Irina A.
dc.contributor.author	Dikusar, Evgenij A.
dc.contributor.author	Terpinskaya, Tatiana I.
dc.contributor.author	Kulchitsky, Vladimir A.
dc.contributor.author	Potkin, Vladimir I.
dc.contributor.author	Pushkarchuk, Alexander L.
dc.contributor.author	Lyakhov, Dmitry A.
dc.contributor.author	Michels, Dominik L.
dc.date.accessioned	2024-09-19T05:01:47Z
dc.date.available	2024-09-19T05:01:47Z
dc.date.issued	2024
dc.identifier.citation	Mukusheva, G.K.; Jalmakhanbetova, R.I.; Shaibek, A.Z.; Nurmaganbetova, M.S.; Zhasymbekova, A.R.; Nurkenov, O.A.; Akishina, E.A.; Kolesnik, I.A.; Dikusar, E.A.; Terpinskaya, T.I.; et al. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells. Molecules 2024, 29, 3246. https://doi.org/10.3390/ molecules29143246	ru
dc.identifier.issn	14203049
dc.identifier.other	doi.org/10.3390/molecules29143246
dc.identifier.uri	http://rep.enu.kz/handle/enu/16631
dc.description.abstract	Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.	ru
dc.language.iso	en	ru
dc.publisher	Molecules	ru
dc.subject	anabasine	ru
dc.subject	cytisine	ru
dc.subject	ureas	ru
dc.subject	isoxazole	ru
dc.subject	cytotoxic activity	ru
dc.subject	antiproliferative activity	ru
dc.subject	drug synergism	ru
dc.subject	molecular docking	ru
dc.subject	quantum chemical modeling	ru
dc.title	Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells	ru
dc.type	Article	ru