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Boron and Gadolinium Loaded Fe3O4 Nanocarriers for Potential Application in Neutron Capture Therapy

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dc.contributor.author Korolkov, Ilya V.
dc.contributor.author Zibert, Alexandr V.
dc.contributor.author Lissovskaya, Lana I.
dc.contributor.author Ludzik, K.
dc.contributor.author Anisovich, M.
dc.contributor.author Kozlovskiy, Artem L.
dc.contributor.author Shumskaya, A. E.
dc.contributor.author Vasilyeva, M.
dc.contributor.author Shlimas, Dmitriy I.
dc.contributor.author Jazd, Monika
dc.contributor.author Marciniak, Beata
dc.contributor.author Kontek, Renata
dc.contributor.author Chudoba, Dorota
dc.contributor.author Zdorovets, Maxim V.
dc.date.accessioned 2024-09-19T09:40:35Z
dc.date.available 2024-09-19T09:40:35Z
dc.date.issued 2021
dc.identifier.citation Korolkov, I.V.; Zibert, A.V.; Lissovskaya, L.I.; Ludzik, K.; Anisovich, M.; Kozlovskiy, A.L.; Shumskaya, A.E.; Vasilyeva, M.; Shlimas, D.I.; Jazd˙ zewska, M.; et al. ˙ Boron and Gadolinium Loaded Fe3O4 Nanocarriers for Potential Application in Neutron Capture Therapy. Int. J. Mol. Sci. 2021, 22, 8687. https://doi.org/10.3390/ ijms22168687 ru
dc.identifier.issn 1422-0067
dc.identifier.other doi.org/10.3390/ijms22168687
dc.identifier.uri http://rep.enu.kz/handle/enu/16663
dc.description.abstract In this article, a novel method of simultaneous carborane- and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe3O4 nanoparticles were treated with silane and then the polyelectrolytic layer was formed for further immobilization of NCT agents. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray (EDX), ultraviolet–visible (UV-Vis) and Mössbauer spectroscopies, dynamic light scattering (DLS), scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) were applied for the characterization of the chemical and element composition, structure, morphology and magnetic properties of nanocarriers. The cytotoxicity effect was evaluated on different cell lines: BxPC-3, PC-3 MCF-7, HepG2 and L929, human skin fibroblasts as normal cells. average size of nanoparticles is 110 nm; magnetization at 1T and coercivity is 43.1 emu/g and 8.1, respectively; the amount of B is 0.077 mg/g and the amount of Gd is 0.632 mg/g. Successful immobilization of NCT agents, their low cytotoxicity against normal cells and selective cytotoxicity against cancer cells as well as the superparamagnetic properties of nanocarriers were confirmed by analyses above. ru
dc.language.iso en ru
dc.publisher International Journal of Molecular Sciences ru
dc.relation.ispartofseries Volume 22;Issue 16
dc.subject superparamagnetic Fe3O4 nanoparticles ru
dc.subject carborane ru
dc.subject gadolinium ru
dc.subject targeted drug delivery ru
dc.subject cytotoxicity ru
dc.subject NCT ru
dc.title Boron and Gadolinium Loaded Fe3O4 Nanocarriers for Potential Application in Neutron Capture Therapy ru
dc.type Article ru


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