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Coumarins of genus Ferula L. (Apiaceae Lindl.)

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dc.contributor.author Khosnutdinova, T.S.
dc.contributor.author Gemejiyeva, N.G.
dc.contributor.author Karzhaubekova, Zh.Zh.
dc.contributor.author Sultanova, N.A.
dc.date.accessioned 2024-09-19T10:04:26Z
dc.date.available 2024-09-19T10:04:26Z
dc.date.issued 2022
dc.identifier.issn 2522-4867
dc.identifier.other doi.org/10.18321/ectj1494
dc.identifier.uri http://rep.enu.kz/handle/enu/16675
dc.description.abstract The biologically active coumarins from Ferula L. species of the family Apiaceae Lindl. for the period 1970 to 2022 have been reviewed. The phytochemical investigation of different parts of Ferula L., including gum resin, leaves, fruits, seeds, roots, rhizomes, and resins led to the separation of different types of coumarins. Nearly 185 coumarins were isolated from 35 species of Ferula L. growing in different countries. Coumarins are represented mainly by umbelliferone (7-O-hydroxycoumarin) derivatives substituted in the C-7 position of aglycone, furanocoumarins and metabolites have terpene fragments, esters and glycosides. Umbelliferon is found as a taxon for the genus Ferula L. Some «unusual» metabolites have a furan fragment attached to the pyrone ring. Coumarins are of the psoralen type, containing a furan ring in the C-6 and C-7 positions of the primary skeleton. The rare coumarins with terpene fragments (hemiterpene, monoterpen, sesquiterpene) were reported. The biological activities of some extracts and individual metabolites such as antiinflammatory, cytotoxicity, antibacterial, antileishmanial, antiviral, antigenotoxic, antitumor, anticoagulant, antioxidant, antimycobacterial, inhibition a-glucosidase, antileishmanial were found. ru
dc.language.iso en ru
dc.publisher Eurasian Chemico-Technological Journal ru
dc.subject Ferula L. ru
dc.subject Coumarins ru
dc.subject Furanocoumarins ru
dc.subject Terpene coumarins ru
dc.subject Ethers ru
dc.subject Glycosides ru
dc.subject Biological activity ru
dc.title Coumarins of genus Ferula L. (Apiaceae Lindl.) ru
dc.type Article ru


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