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Simultaneous Immobilization of Gadolinium Ions and Di(o-carborano-1,2-dimethyl)borate on Fe3O4 Nanoparticles

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dc.contributor.author Korolkov, I.V.
dc.contributor.author Zibert, A.V.
dc.contributor.author Lisovskaya, L.I.
dc.contributor.author Ludzik, K.
dc.contributor.author Anisovich, M.V.
dc.contributor.author Vasilyeva, M.M.
dc.contributor.author Shumskaya, A.E.
dc.contributor.author Usseinov, A.
dc.contributor.author Yeszhanov, A.B.
dc.contributor.author Zdorovets, M.V.
dc.date.accessioned 2024-09-24T10:47:08Z
dc.date.available 2024-09-24T10:47:08Z
dc.date.issued 2022
dc.identifier.citation Korolkov, I.V., Zibert, A.V., Lisovskaya, L.I., Ludzik K., Anisovich, M., Vasilyeva, M., Shumskaya, A., Usseinov, A., Yeszhanov, A.B., & Zdorovets, M.V. (2022) Simultaneous Immobilization of Gadolinium Ions and Di(o-carborano-1,2-dimethyl) borate on Fe3O4 Nanoparticles. Bulletin of the University of Karaganda – Chemistry, 106(2), 87-94. https://doi.org/10.31489/2022Ch2/2-22-3 ru
dc.identifier.issn 2663-4872
dc.identifier.other doi.org/10.31489/2022Ch2/2-22-3
dc.identifier.uri http://rep.enu.kz/handle/enu/16903
dc.description.abstract Neutron capture therapy is a promising method for cancer treatment based on the targeted delivery of specific isotopes into cancer cells and subsequent irradiation with epithermal neutrons. As a result, a large amount of energy is released at a distance comparable to the size of the cell, destroying it from the inside. Magnetic iron oxide nanoparticles can be used for the targeted delivery of isotopes. In this article, iron oxide nanoparticles (Fe3O4) were modified with silanes and polyelectrolyte complexes for simultaneous immobilization of gadolinium ions and carborane compounds through ionic interaction for potential application in targeted delivery into cancer cells for neutron capture therapy. Structure, size and element composition was elucidated by the Fourier-transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDA), dynamic light scattering (DLS) and X-ray diffraction (XRD) analysis. It was found that, according to EDA, resulting nanoparticles consist of 15.4 % boron and 1.5 % gadolinium, with average hydrodynamical size of 386 nm measured by DLS. An in vitro cytotoxicity test using HepG2 (a cancer cell line) and human skin fibroblasts (a normal cell line) showed minor cytotoxicity in concentration range from 0.05 to 1 mg/mL. ru
dc.language.iso en ru
dc.publisher Ķaraġandy universitetìnìn̦ habaršysy. Himiâ seriâsy ru
dc.subject Fe3O4 nanoparticles ru
dc.subject silane ru
dc.subject surface modification ru
dc.subject targeted delivery of payload ru
dc.subject BNCT ru
dc.subject carborane ru
dc.subject cytotoxicity ru
dc.title Simultaneous Immobilization of Gadolinium Ions and Di(o-carborano-1,2-dimethyl)borate on Fe3O4 Nanoparticles ru
dc.type Article ru


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