Abstract:
The paper provides an overview of the use of various betulin derivatives. There are
represented conclusions of in-silico research of betulin, betulinic acid, betulinic diacetate,
allobetulinol. There has been used OSIRIS software for in silico analysis PASS, Molinspiration.
Obtained results of the study show that after summarizing of all forecasts betulin and betulinic
acid are potential compounds for getting more efficient and active products for producing of
antitumor pharmaceuticals. Betulin diacetate is proper according to various theoretic terms but
has a high probability to be an irritant mediator. Also, this substance shows the worst compliance
with Lipinski rule. According to PASS forecast all the investigated compounds have substantial
prospect to be used as the basis for producing new highly effective anticancer pharmaceuticals.
