Abstract:
MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting
the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in
the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria
and are probably derived from mitochondrial DNA. These miRNAs are able to directly regulate
mitochondrial genes and mitochondrial activity. Mitochondrial dysfunction is the cause of many
diseases, including cancer. In this review, we consider the role of mitochondrial miRNAs in the
pathogenesis of lung cancer with particular reference to radon exposure.
