Abstract:
Due to traumatic injuries, including those from surgical procedures, adhesions occur in
over 50% of cases, necessitating exclusive surgical intervention for treatment. However, preventive
measures can be implemented during abdominal organ surgeries. These measures involve creating a
barrier around internal organs to forestall adhesion formation in the postoperative phase. Yet, the
effectiveness of the artificial barrier relies on considerations of its biocompatibility and the avoidance
of adverse effects on the body. This study explores the biocompatibility aspects, encompassing
hemocompatibility, cytotoxicity, and antibacterial and antioxidant activities, as well as the adhesion
of blood serum proteins and macrophages to the surface of new composite film materials. The
materials, derived from the sodium salt of carboxymethylcellulose modified by glycoluril and
allantoin, were investigated. The research reveals that film materials with a heterocyclic fragment
exhibit biocompatibility comparable to commercially used samples in surgery. Notably, film samples
developed with glycoluril outperform the effects of commercial samples in certain aspects.
