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The Determination of the Biocompatibility of New Compositional Materials, including Carbamide-Containing Heterocycles of Anti-Adhesion Agents for Abdominal Surgery

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dc.contributor.author Kanasheva, Nurdana
dc.contributor.author Fedorishin, Dmitry A.
dc.contributor.author Lyapunova, Maria V.
dc.contributor.author Bukterov, Mikhail V.
dc.contributor.author Kaidash, Olga A.
dc.contributor.author Bakibaev, Abdigali A.
dc.contributor.author Yerkassov, Rakhmetulla
dc.contributor.author Mashan, Togzhan
dc.contributor.author Nesmeyanova, Rimma
dc.contributor.author Ivanov, Vladimir V.
dc.contributor.author Udut, Elena V.
dc.contributor.author Tuguldurova, Vera P.
dc.contributor.author Salina, Margarita V.
dc.contributor.author Malkov, Victor S.
dc.contributor.author Knyazev, Alexey S.
dc.date.accessioned 2024-09-18T07:31:06Z
dc.date.available 2024-09-18T07:31:06Z
dc.date.issued 2024
dc.identifier.citation Kanasheva, N.; Fedorishin, D.A.; Lyapunova, M.V.; Bukterov, M.V.; Kaidash, O.A.; Bakibaev, A.A.; Yerkassov, R.; Mashan, T.; Nesmeyanova, R.; Ivanov, V.V.; et al. The Determination of the Biocompatibility of New Compositional Materials, including Carbamide-Containing Heterocycles of Anti-Adhesion Agents for Abdominal Surgery. Molecules 2024, 29, 851. https://doi.org/10.3390/ molecules29040851 ru
dc.identifier.issn 1420-3049
dc.identifier.other doi.org/10.3390/molecules29040851
dc.identifier.uri http://rep.enu.kz/handle/enu/16600
dc.description.abstract Due to traumatic injuries, including those from surgical procedures, adhesions occur in over 50% of cases, necessitating exclusive surgical intervention for treatment. However, preventive measures can be implemented during abdominal organ surgeries. These measures involve creating a barrier around internal organs to forestall adhesion formation in the postoperative phase. Yet, the effectiveness of the artificial barrier relies on considerations of its biocompatibility and the avoidance of adverse effects on the body. This study explores the biocompatibility aspects, encompassing hemocompatibility, cytotoxicity, and antibacterial and antioxidant activities, as well as the adhesion of blood serum proteins and macrophages to the surface of new composite film materials. The materials, derived from the sodium salt of carboxymethylcellulose modified by glycoluril and allantoin, were investigated. The research reveals that film materials with a heterocyclic fragment exhibit biocompatibility comparable to commercially used samples in surgery. Notably, film samples developed with glycoluril outperform the effects of commercial samples in certain aspects. ru
dc.language.iso en ru
dc.publisher Molecules ru
dc.relation.ispartofseries Volume 29;Issue 4
dc.subject anti-adhesion agents ru
dc.subject carbamide-containing heterocycles ru
dc.subject composite materials ru
dc.subject barrier films ru
dc.subject biocompatibility ru
dc.subject surgery ru
dc.title The Determination of the Biocompatibility of New Compositional Materials, including Carbamide-Containing Heterocycles of Anti-Adhesion Agents for Abdominal Surgery ru
dc.type Article ru


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