Аннотации:
This study mainly deals with an effective one-pot
solvothermal synthetic pathway for the preparation of uniformly dispersed
zirconium oxide nanoparticles on the flattened rough surface of reduced
graphene oxide (ZrO2/rGO NCs) using the aqueous leaf extract of
Andrographis paniculata. After obtaining detailed information on the
preparation and characterization, the anticancer activity of the synthesized
ZrO2/rGO nanocrystals (NCs) was evaluated on two human cancer cell
lines (A549 and HCT116) along with one normal human cell line
(hMSC). The 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide assays revealed that ZrO2/rGO NCs exhibited a dose-dependent
cytotoxicity pattern. The cell viability (%) drastically decreases up to 96−
98% after exposure to an optimal concentration of 10 ppm nanocomposites. Analysis of both the reactive oxygen species generation and
the Annexin V-FTIC staining assays reveal that ZrO2/rGO NCs have the ability to induce apoptosis in A549 and HCT116 cell lines.
Thus, the green synthesis of ZrO2/rGO NCs shows potential in developing efficient therapeutic agents for cancer therapy
