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dc.contributor.author | Kadiyala, Nalinee Kanth | |
dc.contributor.author | Mandal, Badal Kumar | |
dc.contributor.author | Mandal, B.K. | |
dc.contributor.author | Reddy, L. Vinod Kumar | |
dc.contributor.author | Barnes, Crispin H.W. | |
dc.contributor.author | De Los Santos Valladares, Luis | |
dc.contributor.author | Sen, Dwaipayan | |
dc.date.accessioned | 2024-09-18T09:54:19Z | |
dc.date.available | 2024-09-18T09:54:19Z | |
dc.date.issued | 2023-01 | |
dc.identifier.issn | 24701343 | |
dc.identifier.other | DOI 10.1021/ACSOMEGA.2C06822 | |
dc.identifier.uri | http://rep.enu.kz/handle/enu/16614 | |
dc.description.abstract | This study mainly deals with an effective one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed zirconium oxide nanoparticles on the flattened rough surface of reduced graphene oxide (ZrO2/rGO NCs) using the aqueous leaf extract of Andrographis paniculata. After obtaining detailed information on the preparation and characterization, the anticancer activity of the synthesized ZrO2/rGO nanocrystals (NCs) was evaluated on two human cancer cell lines (A549 and HCT116) along with one normal human cell line (hMSC). The 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide assays revealed that ZrO2/rGO NCs exhibited a dose-dependent cytotoxicity pattern. The cell viability (%) drastically decreases up to 96− 98% after exposure to an optimal concentration of 10 ppm nanocomposites. Analysis of both the reactive oxygen species generation and the Annexin V-FTIC staining assays reveal that ZrO2/rGO NCs have the ability to induce apoptosis in A549 and HCT116 cell lines. Thus, the green synthesis of ZrO2/rGO NCs shows potential in developing efficient therapeutic agents for cancer therapy | ru |
dc.language.iso | en | ru |
dc.publisher | ACS Omega | ru |
dc.relation.ispartofseries | Том 8, Выпуск 2,;Страницы 2406 - 2420 | |
dc.title | Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites: Evaluation of Their Enhanced Anticancer Activity toward Human Cancer Cell Lines | ru |
dc.type | Article | ru |