dc.contributor.author |
Kadiyala, Nalinee Kanth |
|
dc.contributor.author |
Mandal, Badal Kumar |
|
dc.contributor.author |
Mandal, B.K. |
|
dc.contributor.author |
Reddy, L. Vinod Kumar |
|
dc.contributor.author |
Barnes, Crispin H.W. |
|
dc.contributor.author |
De Los Santos Valladares, Luis |
|
dc.contributor.author |
Sen, Dwaipayan |
|
dc.date.accessioned |
2024-09-18T09:54:19Z |
|
dc.date.available |
2024-09-18T09:54:19Z |
|
dc.date.issued |
2023-01 |
|
dc.identifier.issn |
24701343 |
|
dc.identifier.other |
DOI 10.1021/ACSOMEGA.2C06822 |
|
dc.identifier.uri |
http://rep.enu.kz/handle/enu/16614 |
|
dc.description.abstract |
This study mainly deals with an effective one-pot
solvothermal synthetic pathway for the preparation of uniformly dispersed
zirconium oxide nanoparticles on the flattened rough surface of reduced
graphene oxide (ZrO2/rGO NCs) using the aqueous leaf extract of
Andrographis paniculata. After obtaining detailed information on the
preparation and characterization, the anticancer activity of the synthesized
ZrO2/rGO nanocrystals (NCs) was evaluated on two human cancer cell
lines (A549 and HCT116) along with one normal human cell line
(hMSC). The 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide assays revealed that ZrO2/rGO NCs exhibited a dose-dependent
cytotoxicity pattern. The cell viability (%) drastically decreases up to 96−
98% after exposure to an optimal concentration of 10 ppm nanocomposites. Analysis of both the reactive oxygen species generation and
the Annexin V-FTIC staining assays reveal that ZrO2/rGO NCs have the ability to induce apoptosis in A549 and HCT116 cell lines.
Thus, the green synthesis of ZrO2/rGO NCs shows potential in developing efficient therapeutic agents for cancer therapy |
ru |
dc.language.iso |
en |
ru |
dc.publisher |
ACS Omega |
ru |
dc.relation.ispartofseries |
Том 8, Выпуск 2,;Страницы 2406 - 2420 |
|
dc.title |
Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites: Evaluation of Their Enhanced Anticancer Activity toward Human Cancer Cell Lines |
ru |
dc.type |
Article |
ru |