Abstract:
The problem of tumour therapy has attracted the attention of many researchers for many
decades. One of the promising strategies for the development of new dosage forms to improve
oncology treatment efficacy and minimise side effects is the development of nanoparticle-based
targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica
deserves special attention due to its outstanding surface properties and drug-loading capability.
This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of
safe and effective drug delivery systems. Special attention is paid to technological approaches to
chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release
from nanoparticles are also discussed, contributing to the effective control of the delivery process in
the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug
delivery systems.
